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Phenylarthrite shows a true potentiation of the anti-inflammatory effects of the drugs alone.
Thanks to phenylbutazone, there is a strong inhibition of the action of the enzyme cyclooxygenase (COX-2) in the production of mediators of inflammation. Dexamethasone, on the other hand, inhibits the expression of COX-2, inhibiting the transcription of the relevant gene and, in this way, reduces the generation of prostaglandins responsible for the symptoms of inflammation.
Phenylarthrite Fort CONTRAINDICATIONS:
The use of corticosteroid preparations in acute infections should be avoided. When used in non-acute infectious conditions, treatment should be associated with bactericidal antibiotics to the detriment of bacteriostatic antibiotics.
In general, corticosteroids are contraindicated in viral infections and late in pregnancy, when they can induce labor. They should also not be administered to animals that have renal, cardiac and hepatic insufficiency, gastric ulcer and that are hypersensitive to the components of the formula. Its use is not recommended in animals with diabetes mellitus, osteoporosis and hemato cytological alterations (aplastic anemia, leukopenia, agranulocytosis and thrombocytopenia). Do not apply to newborn animals.
Treatment duration:
Use higher doses for the first 48 hours, then the dose is gradually reduced to a maintenance level and is maintained at a lower level capable of achieving a desired clinical response. Treatment varies from 3 to 14 days (average of 7 days in horses) and 3 days in canines.
Drug interactions:
There are risks of drug interactions occurring when Phenylbutazone is administered with other non-steroidal anti-inflammatory agents, as they have a similar mechanism of action (cyclooxygenase inhibition) which may increase the occurrence of adverse effects.
Withdrawal period for the Injectable Phenylarthrite product:
Cattle: Slaughter: 14 days. Milk: 05 days.
Pigs: Slaughter: 14 days.
Horses: This product must not be applied to horses intended for slaughter for human consumption.
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From a biochemical layout perspective, the major active mechanism driving Phenylarthrite Fort utilizes the specialized pyrazolidinedione derivative known as phenylbutazone sodium. Systematically recognized as 4-butyl-1,2-diphenylpyrazolidine-3,5-dione, its base chemical structure features a molecular formula of $C_{19}H_{20}N_2O_2$ paired with a formula mass of $308.38 \text{ g/mol}$.
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Phenylarthrite fort with dexamethasone that enhances the anti-inflammatory, antipyretic and analgesic effect of the product.Combination of that enhances the anti-inflammatory, antipyretic and analgesic effect of the product.
Presentation: 100mL bottles.
Slow intravenous route
Application every 24 or 48 hours as follows:
Adult horses: 3 to 4 mL / 100 kg body mass.
Foals: 1 to 2 mL / 50 kg body mass.
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Phenylarthrite 100 ml phenylbutazone bute is used for the treatment of inflammation, pain and fever, particularl in the case of muscoskeletal disorders, congestive processes or inflammatory complications following traumatic of infectious affections.
Composition
Phenylbutazone 200 mg/ml
Indication
Arthritis, tendonitis, joint- and muscle rheumatism, hyperthermia, inflammations caused by trauma or bacteria.Dosage and administration
Horses: I.V.: inject slowly 20 ml daily or every other day, depending on the severity of the disorder.
I.M.: inject deeply 20 to 30 ml on day 1.Phenylarthrite fort
20 ml on day 2.
10 ml the following 1 to 4 days.
If necessary a second series of injections may be administered after 1 to 2 weeks.
Do not exceed the recommended dosage. If there is no improvement after 6 days discontinue t
Use strict sterile conditions.Contraindications
Heart-, liver and kidney insufficiency.Withholding period
Do not use in animals intended for food.Warnings
It is recommended to decrease the dose or to discontinue treatment in animals with weak veins or with coagulation problems.Storage
Store at 15 – 25°C.
Keep out of reach and sight of children.Presentation
100 ml bottle
Phenylarthrite 100 ml phenylbutazone bute is used for the treatment of inflammation, pain and fever, particularl in the case of muscoskeletal disorders, congestive processes or inflammatory complications following traumatic of infectious affections.Phenylarthrite fort
Composition
Phenylbutazone 200 mg/ml
Indication
Phenylarthrite Fort Dosage and administration
Arthritis, tendonitis, joint- and muscle rheumatism, hyperthermia, inflammations caused by trauma or bacteria.Dosage and administration
Horses: I.V.: inject slowly 20 ml daily or every other day, depending on the severity of the disorder.
I.M.: inject deeply 20 to 30 ml on day 1.
20 ml on day 2.
10 ml the following 1 to 4 days.Phenylarthrite fort
If necessary a second series of injections may be administered after 1 to 2 weeks.
Do not exceed the recommended dosage. If there is no improvement after 6 days discontinue treatment.Precautions
Use strict sterile conditions.Contraindications
Heart-, liver and kidney insufficiency.Withholding period
Do not use in animals intended for food.Warnings
It is recommended to decrease the dose or to discontinue treatment in animals with weak veins or with coagulation problems.Storage
Store at 15 – 25°C.
Keep out of reach and sight of Phenylarthrite fort

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