Prodexan 100ml contains as an active substance: dexamethasone (in the form of disodium phosphate) – 2 mg sodium metabisulfite – 1 mg, methyl parahydroxybenzoate – 1 mg, propyl parahydroxybenzoate – 0.1 mg, disodium phosphate dodecahydrate – 13.5 mg and water for injection.
Pharmacological properties
Dexamethasone 2 mg/cm3 belongs to the group of synthetic glucocorticosteroids.
It has a pronounced anti-inflammatory, anti-allergic, desensitizing effect and immunosuppressive activity.
The mechanism of action of the hormone is to block the release of inflammatory mediators by eosinophils, including prostaglandins, which potentiate the inflammatory process, stimulate the biosynthesis of lipocartins with anti-edematous activity, reduce the number of mast cells that produce hyaluronic acid, and reduce capillary permeability. The immunosuppressive effect is due to inhibition of the release of cytokines (interleukin 1,2, gamma-interferon) from lymphocytes and macrophages, inhibition of the proliferation of lymphoid tissue and cellular immunity, and impaired kinetics of T-lymphocytes.
The main effect of dexamethasone on metabolism is associated with protein catabolism, an increase in gluconeogenesis in the liver, and a decrease in glucose utilization by peripheral tissues.
The maximum concentration after parenteral administration of dexamethasone in blood plasma is detected after 60 minutes. Therapeutic concentration in blood serum lasts up to 48 hours, depending on the type of animal. The bioavailability of dexamethasone with intramuscular administration of the drug is 100%, its biotransformation occurs in the liver and partly in the fibroblasts involved in the metabolic process. Dexamethasone is excreted as metabolites, mainly in urine and bile.
Dexamethasone 2 mg/cm3 is a moderately hazardous substance according to the degree of impact on the body (hazard class 3 according to GOST 12.1.007-76).
Application procedure
Dexamethasone 2 mg/cm3 is prescribed for cattle and small cattle, pigs, sport and work horses, dogs and cats as an anti-inflammatory, antiallergic, decongestant and gluconeogenetic agent in the treatment of post-traumatic edema, arthritis, tendovaginitis, as well as acute mastitis and ketosis in cattle cattle, allergic dermatitis and eczema in dogs and cats.
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Dexamethasone 2 mg/cm3 is administered to animals once intramuscularly at the following doses (per animal):
adult cattle and horses – 5 – 15 ml;
sheep, goats, pigs, calves and foals – 1 – 2.5 ml;
dogs – 0.1 – 1 ml;
cats – 0.1 – 1 ml.
A single injection of the drug is provided. If necessary, the injection is repeated at the same dose after 24 hours.prodexan 100ml prodexan 100ml
Contraindications
A contraindication to the use of Dexamethasone is the increased individual sensitivity of the animal to the components of the drug, hypertensive keratitis and other viral infections of the cornea and conjunctiva, infections caused by mycobacteria, glaucoma.
Do not use Dexamethasone 2 mg/cm3 in females during the last third of pregnancy.
Dexamethasone 2 mg/cm3 should not be used in conjunction with other glucocorticosteroids, immunobiological drugs, barbiturates, antihistamines and antidiabetics, diuretics that remove potassium, salicylates, calcium salts, tetracyclines,
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